In order to evaluate the antiallergic effects of CSYJT, studies were done. We measured the cytotoxic activity for cytokines transcript expression, production of IL-4, IgE, IFN-ν, proliferation of B cell in HRF plus anti-CD40mAb plus rIL-4 stimulated murine splenic B cells, and cytokines transcript expression of IgE in Mast cell.
The results were obtained as follows :
1. CSYJT decreased the expression of IL-4 in mast cell significantly.
2. CSYJT decreased the production of IL-4 significantly.
3. CSYJT decreased the expression of IgE in mast cell significantly.
4. CSYJT decreased the production of IgE significantly.
5. CSYJT increased the appearance of IFN-ν.
The facts above prove that CSYJT is effective against the allergy. Thus, I think that we should study on this continuously.
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